Text 1 Growth in the use of novel nanohybrids—materials created from the conjugation of multiple distinct nanomaterials, such as iron oxide and gold nanomaterials conjugated for use in magnetic imaging—has outpaced studies of nanohybrids’ environmental risks. Unfortunately, risk evaluations based on nanohybrids’ constituents are not reliable: conjugation may alter constituents’ physiochemical properties such that innocuous nanomaterials form a nanohybrid that is anything but. Text 2 The potential for enhanced toxicity of nanohybrids relative to the toxicity of constituent nanomaterials has drawn deserved attention, but the effects of nanomaterial conjugation vary by case. For instance, it was recently shown that a nanohybrid of silicon dioxide and zinc oxide preserved the desired optical transparency of zinc oxide nanoparticles while mitigating the nanoparticles’ potential to damage DNA.